The New York Times has a new article about the the reactions of real scientists to The Big Bang Theory.  They also chat with the cast about their opinions.

Three years later some scientists still say that although the series, “The Big Bang Theory” (Monday nights on CBS), is funny and scientifically accurate, they are put off by it. “Makes me cringe,” said Bruce Margon, an astrophysicist at the University of California, Santa Cruz, explaining, “The terrible stereotyping of the nerd plus the dumb blond are steps backwards for science literacy.”

Lisa Randall, a Harvard particle theorist who has visited the show’s set twice and appeared as an uncredited extra in one scene said, “I do think the writers are genuinely clever.” Lawrence Krauss, a cosmologist at Arizona State, and author of “The Physics of Star Trek,” said he had changed his initial dire opinion about the program. “First, because it is funny, and continues to be,” he said. “Second, because the characters have developed softer edges, and one of them has the girl!”

The point of the show, Mr. Prady said, is to tell small stories. “We are not doing ‘Lost,’ we’re not doing a complex novel for TV,” he said. “We follow the characters, and let them tell us what they’re going to do next. We’re telling stories about outsiders. We all feel like outsiders. Can you find love? Penny pulls Leonard to the outside world; Sheldon pulls him back.” Mr. Lorre said that the whole “challenge and joy” of a series like this is character development. “Maybe at the end of the day this will inspire some kids to go into physics,” he added, “just like ‘Cheers’ inspired countless young people to go into bars.”